BMS-986242 | IDO1 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-986242

CAS No.: 1923844-48-7

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BMS-986242 (BMS986242)

货号: PC-72378Not For Human Use, Lab Use Only.

BMS-986242 (BMS986242) is a potent, selective IDO1 inhibitor with IC50 of 2 nM in cellular IDO1 inhibition assays and IC50 of 25 nM in human whole blood (HWB) IDO1 inhibition assays.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4880	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BMS-986242 (BMS986242) is a potent, selective IDO1 inhibitor with IC50 of 2 nM in cellular IDO1 inhibition assays and IC50 of 25 nM in human whole blood (HWB) IDO1 inhibition assays.
BMS-986242 shows activity against a variety of cancers including metastatic melanoma and renal cell carcinoma.
BMS-986242 elicited a PD effect comparable to linrodostat and epacadostat in a PD model of tumor kynurenine reduction at a lower level of exposure.
BMS-986242 is a structurally differentiated clinical candidate that performs comparably to linrodostat (BMS-986205) in terms of both in vitro potency and in vivo pharmacodynamic effect in a mouse xenograft model.

物理化学性质&存储条件

分子量	410.917
分子式	C24H24ClFN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-N-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide

参考文献

1. Cherney EC, et al. ACS Med Chem Lett. 2021 Jan 28;12(2):288-294.

BMS-986242 (BMS986242)

生物&药学活性

物理化学性质&存储条件

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BMS-986242 (BMS986242)

生物&药学活性

物理化学性质&存储条件

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