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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-BMS-986195
BMS-986195

Chemical Structure : BMS-986195

CAS No.: 1912445-55-6

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BMS-986195 (BMS986195, Branebrutinib)

货号: PC-63295Not For Human Use, Lab Use Only.

BMS-986195 (Branebrutinib) is a novel potent, selective, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with IC50 of 0.1 nM.

规格 价格 库存 数量
1 mg (Free Sample) ￥180 In stock
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-986195 (Branebrutinib) is a novel potent, selective, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with IC50 of 0.1 nM.
BMS-986195 (Branebrutinib) displays >5,000-fold selective over all kinases outside of the Tec family, and selectivity ranges 9- to 1010-fold within the Tec family.
BMS-986195 (Branebrutinib) potently inhibits antigen-dependent interleukin-6 production, CD86 expression and proliferation in B cells (IC50<1 nM).
BMS-986195 (Branebrutinib) demonstrates robust efficacy in murine models of RA including CIA and CAIA, protecting against clinically evident disease, histologic joint damage and bone mineral density loss.

物理化学性质&存储条件

分子量 370.428
分子式 C20H23FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

参考文献

1. Watterson SH, et al. J Med Chem. 2019 Apr 11;62(7):3228-3250.
2. Catlett IM, et al. Br J Clin Pharmacol. 2020 Sep;86(9):1849-1859.
3. Wu CP, et al. Front Cell Dev Biol. 2021 Jul 19;9:699571.

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