BMS-986169 |CAS:1801151-08-5 Probechem Biochemicals

Chemical Structure : BMS-986169

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BMS-986169 (BMS986169)

货号: PC-35166Not For Human Use, Lab Use Only.

BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells.

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生物&药学活性

BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells.
BMS-986169 shows negligible activity in an assay panel containing 40 additional pharmacological targets, and weakly inhibits hERG channel; produces a transient working memory impairment in monkeys.
BMS-986169 does not produce ketamine-like hyperlocomotion or abnormal behaviors in mice or cynomolgus monkeys.

物理化学性质&存储条件

分子量	382.479
分子式	C23H27FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one

参考文献

1. Marcin LR, et al. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477.

2. Bristow LJ, et al. J Pharmacol Exp Ther. 2017 Dec;363(3):377-393.

BMS-986169 (BMS986169)

生物&药学活性

物理化学性质&存储条件

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BMS-986169 (BMS986169)

生物&药学活性

物理化学性质&存储条件

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