BMS-986141 | PAR4 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-986141

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BMS-986141 (BMS986141)

货号: PC-20965Not For Human Use, Lab Use Only.

BMS-986141 is a potent, selective antagonist of protease-activated receptor 4 (PAR4) with IC50 of 0.4 nM, Kd of 0.1 nM.

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生物&药学活性

BMS-986141 is a potent, selective antagonist of protease-activated receptor 4 (PAR4) with IC50 of 0.4 nM, Kd of 0.1 nM.
BMS-986141 potently inhibits platelet aggregation induced with a PAR4 agonist peptide (25 μM) with IC50 of 2.2 nM.
BMS-986141 shows no effect on platelet aggregation induced by a PAR1 antagonist peptide, adenosine diphosphate, collagen, or the thromboxane A2 receptor agonist U46619 up to 1 uM.
BMS-986141 (0.5 and 1 mg/kg) demonstrated excellent antithrombotic efficacy and minimal bleeding time prolongation in monkey models relative to the clinically important antiplatelet agent clopidogrel.

物理化学性质&存储条件

分子量	561.63
分子式	C27H23N5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)thiazol-2-yl)-N,N-dimethylbenzamide

参考文献

1. E Scott Priestley, et al. J Med Chem. 2022 Jul 14;65(13):8843-8854.

BMS-986141 (BMS986141)

生物&药学活性

物理化学性质&存储条件

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BMS-986141 (BMS986141)

生物&药学活性

物理化学性质&存储条件

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