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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-BMS-986124
BMS-986124

Chemical Structure : BMS-986124

CAS No.: 1447968-71-9

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BMS-986124 (BMS986124)

货号: PC-22781Not For Human Use, Lab Use Only.

BMS-986124 is a small molecule silent allosteric modulator (SAM) of μ-opioid receptor (MOR), blocks the effects of the MOR positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMS-986124 is a small molecule silent allosteric modulator (SAM) of μ-opioid receptor (MOR), blocks the effects of the MOR positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO.

物理化学性质&存储条件

分子量 448.77
分子式 C16H15BrClNO3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-Bromo-2-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine

参考文献

1. Kaneko S, et al. Nat Commun. 2024 May 13;15(1):3544.

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