BMS-986120 |CAS:1478712-37-6 Probechem Biochemicals

Chemical Structure : BMS-986120

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BMS-986120 (BMS 986120;BMS986120)

货号: PC-60548Not For Human Use, Lab Use Only.

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.

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生物&药学活性

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
BMS-986120 selectivity inhibits PAR4 AP-induced cellular calcium mobilization in HEK cells with IC5o of 0.56 nM, with no activity on PAR1 and PAR2.
BMS-986120 inhibits human PRP aggregation in response to γ-thrombin in vitro with IC50 of 7.3 nM.
BMS-986120 demonstrates potent and highly efficacious antithrombotic activity with low bleeding in vivo.

物理化学性质&存储条件

分子量	513.587
分子式	C23H23N5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-5-methylthiazol-2-yl)morpholine

参考文献

1. Wong PC, et al. Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294.

2. Moschonas IC, et al. Platelets. 2017 Dec;28(8):812-821.

3. Wilson SJ, et al. Arterioscler Thromb Vasc Biol. 2017 Dec 21. pii: ATVBAHA.117.310104.

BMS-986120 (BMS 986120;BMS986120)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-986120 (BMS 986120;BMS986120)

生物&药学活性

物理化学性质&存储条件

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