BMS-986118 |CAS:1610562-74-7 Probechem Biochemicals

Chemical Structure : BMS-986118

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BMS-986118 (BMS986118)

货号: PC-63298Not For Human Use, Lab Use Only.

BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).

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生物&药学活性

BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).
BMS-986118 demonstrates insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models.

物理化学性质&存储条件

分子量	540.968
分子式	C25H28ClF3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4S,5S)-1-(4-(((3R,4R)-1-(5-Chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

参考文献

1. Shi J, et al. J Med Chem. 2018 Feb 8;61(3):681-694.

BMS-986118 (BMS986118)

生物&药学活性

物理化学性质&存储条件

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BMS-986118 (BMS986118)

生物&药学活性

物理化学性质&存储条件

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