BMS-984923 | mGluR5 modulator | Probechem Biochemicals

Chemical Structure : BMS-984923

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BMS-984923 (BMS984923, BMS 984923)

货号: PC-35962Not For Human Use, Lab Use Only.

BMS-984923 (BMS 984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling.

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生物&药学活性

BMS-984923 (BMS 984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling.
BMS-984923 does not affect glutamate/DHPG ((S)-3,5-Dihydroxyphenylglycine)-induced Ca2+ signaling in mGluR5-overexpressing HEK293T cells and cultured nureons.
BMS-984923 reduces the interaction of PrPC with mGluR5 in membrane fractions, prevents Aβo-induced signal transduction in brain slices, and rescues memory deficits and synaptic depletion in the APPswe/PS1ΔE9 transgenic mouse brain.

物理化学性质&存储条件

分子量	374.824
分子式	C22H15ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Oxazolidinone, 5-(2-chlorophenyl)-4-[5-(2-phenylethynyl)-3-pyridinyl]-, (4R,5R)-

参考文献

1. Huang H, et al. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4165-9.

2. Haas LT, et al. Cell Rep. 2017 Jul 5;20(1):76-88.

BMS-984923 (BMS984923, BMS 984923)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-984923 (BMS984923, BMS 984923)

生物&药学活性

物理化学性质&存储条件

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