BMS-955829 | mGluR5 PAM | Probechem Biochemicals

Chemical Structure : BMS-955829

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BMS-955829 (BMS 955829, BMS955829)

货号: PC-61070Not For Human Use, Lab Use Only.

BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).

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生物&药学活性

BMS-955829 is a potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).
BMS-955829 displays no any measurable PAM, NAM or agonist activity at other mGluRs (>10 uM).
BMS-955829 reverses MK-801 induced deficits in executive function in rats, demonstrates robust in vivo efficacy in preclinical models of schizophrenia.

物理化学性质&存储条件

分子量	376.363
分子式	C22H14F2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one

参考文献

1. Yang F, et al. ACS Med Chem Lett. 2016 Jan 4;7(3):289-93.

2. Narang AS, et al. Eur J Pharm Biopharm. 2017 Aug;117:333-345.

BMS-955829 (BMS 955829, BMS955829)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-955829 (BMS 955829, BMS955829)

生物&药学活性

物理化学性质&存储条件

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