BMS-935177 |CAS:1231889-53-4 Probechem Biochemicals

Chemical Structure : BMS-935177

CAS No.: 1231889-53-4

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BMS-935177 (BMS935177)

货号: PC-61491Not For Human Use, Lab Use Only.

BMS-935177 is a potent and selective, orally bioavailable, reversible BTK inhibitor with IC50 of 2.8 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BMS-935177 is a potent and selective, orally bioavailable, reversible BTK inhibitor with IC50 of 2.8 nM.
BMS-935177 displays 5-67-fold selectivity over Tec family kinases, 7-fold selectivity over BLK, and 56-fold over Lck in panel of 384 kinases.
BMS-935177 effectively inhibits TNFα production in PBMCs (IC50=14 nM), inhibits CD69 surface expression in human and mouse whole blood (IC50=0.55 and 2.06 uM, respectively).
BMS-935177 shows profound efficacy in the CAIA and CIA models of arthritis.

物理化学性质&存储条件

分子量	502.574
分子式	C31H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide

参考文献

1. De Lucca GV, et al. J Med Chem. 2016 Sep 8;59(17):7915-35.

BMS-935177 (BMS935177)

生物&药学活性

物理化学性质&存储条件

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BMS-935177 (BMS935177)

生物&药学活性

物理化学性质&存储条件

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