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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-BMS-932481
BMS-932481

Chemical Structure : BMS-932481

CAS No.: 1263871-36-8

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BMS-932481 (BMS932481, BMS 932481)

货号: PC-36082Not For Human Use, Lab Use Only.

BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.

规格 价格 库存 数量
2 mg ￥2880 In stock
5 mg ￥4580 In stock
10 mg ￥7280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: 99.71% (HPLC) Select Batch:

生物&药学活性

BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.
BMS-932481 showed robust reductions of Aβ1–42 and Aβ1–40 in the plasma, brain, and cerebrospinal fluid of mice and rats.
Consistent with the γ-secretase modulator mechanism, increases in Aβ1–37 and Aβ1–38 were observed, with no change in the total amount of Aβ1–x produced.

物理化学性质&存储条件

分子量 445.502
分子式 C24H24FN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-7-(4-fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

参考文献

1. Soares HD, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):138-50.

2. Toyn JH, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37.

3. Kenneth M. Boy, et al. ACS Med. Chem. Lett., February 17, 2019. DOI: 10.1021/acsmedchemlett.8b00541.

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