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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-BMS-929075
BMS-929075

Chemical Structure : BMS-929075

CAS No.: 1217338-97-0

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BMS-929075 (BMS 929075, BMS929075)

货号: PC-60427Not For Human Use, Lab Use Only.

A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-929075 is a highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.
BMS-929075 possesses excellent pharmacokinetic parameters across preclinical animal species.

物理化学性质&存储条件

分子量 538.5548
分子式 C31H24F2N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Fluoro-2-(4-fluorophenyl)-N-methyl-5-[2-methyl-5-[[[1-(2-pyrimidinyl)cyclopropyl]amino]carbonyl]phenyl]-3-benzofurancarboxamide

参考文献

1. Yeung KS, et al. J Med Chem. 2017 May 25;60(10):4369-4385.

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