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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-BMS-911543
BMS-911543

Chemical Structure : BMS-911543

CAS No.: 1271022-90-2

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BMS-911543 (BMS911543;BMS 911543)

货号: PC-44289Not For Human Use, Lab Use Only.

BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM.
BMS-911543 displays 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively.
BMS-911543 displays anti-proliferative effect on JAK2(V617F) MPNs and inhibits pSTAT5 in Ba/FJAK2V617F cells (IC50=60 nM).
BMS-911543 is highly active in in vivo models and orally bioactive.

物理化学性质&存储条件

分子量 432.5214
分子式 C23H28N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide,N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-

参考文献

1. Purandare AV, et al. Leukemia. 2012 Feb;26(2):280-8.

2. Wan H, et al. ACS Med Chem Lett. 2015 Jul 12;6(8):850-5.

3. Mace TA, et al. Oncotarget. 2015 Dec 29;6(42):44509-22.

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