BMS-911172 | AAK1 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-911172

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BMS-911172 (BMS 911172)

货号: PC-20649Not For Human Use, Lab Use Only.

BMS-911172 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.

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生物&药学活性

BMS-911172 (BMS 911172) is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.
BMS-911172 exhibits good overall kinase selectivity in a panel consisting of 391 kinases (Ambit/DiscoverX/Eurofins).
BMS-911172 (60 mg/kg, sc) effectively reduced μ2 phosphorylation following acute administration in C57BL6 mice.
BMS-911172 (30 mg/kg, sc) reduces phase II formalin nociceptive behaviors in rats.
BMS-911172 (60 mg/kg, sc) reduces thermal hyperalgesia and mechanical hyperalgesia in CCI rats.

物理化学性质&存储条件

分子量	339.34
分子式	C16H19F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-amino-N-(3-(difluoromethoxy)-4-(oxazol-5-yl)phenyl)-4-methylpentanamide

参考文献

1. Richard A Hartz, et al. J. Med. Chem. 2021, 64, 15, 11090–11128.

BMS-911172 (BMS 911172)

生物&药学活性

物理化学性质&存储条件

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BMS-911172 (BMS 911172)

生物&药学活性

物理化学性质&存储条件

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