BMS-852927 |CAS:1256918-39-4 Probechem Biochemicals

Chemical Structure : BMS-852927

CAS No.: 1256918-39-4

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BMS-852927 (BMS852927;XL-041;XL041)

货号: PC-61593Not For Human Use, Lab Use Only.

BMS-852927 (XL041) is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively.

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10 mg	￥4280	In stock
25 mg	￥7280	In stock
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生物&药学活性

BMS-852927 (XL041) is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively.
BMS-852927 demonstrates robust LXRβ activity (88%, EC50=24 nM) with low partial LXRα agonist activity (<25%) in cell assays.
BMS-852927 exhibits desired blood cell ABCG1 gene induction in cynomolgus monkeys with limited elevation of plasma triglycerides.
BMS-852927 has favorable combination of in vitro properties, excellent pharmacokinetic parameters, and a favorable lipid profile.

物理化学性质&存储条件

分子量	609.51
分子式	C29H28Cl2F2N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol

参考文献

1. Kick EK, et al. ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212.

2. Kirchgessner TG, et al. Cell Metab. 2016 Aug 9;24(2):223-33.

BMS-852927 (BMS852927;XL-041;XL041)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-852927 (BMS852927;XL-041;XL041)

生物&药学活性

物理化学性质&存储条件

参考文献

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