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首页-小分子抑制剂&激动剂-GPCR-Melanin-concentrating Hormone Receptor (MCHR)-BMS-814580
BMS-814580

Chemical Structure : BMS-814580

CAS No.: 1197420-11-3

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BMS-814580 (BMS814580)

货号: PC-61118Not For Human Use, Lab Use Only.

BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
    BMS-814580 exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM.
    BMS-814580 dose-dependently reduces body weight in a chronic diet-induced obese model.

    物理化学性质&存储条件

    分子量 504.933
    分子式 C24H19ClF2N2O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

    参考文献

    1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858.

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