BMS-779788 |CAS:918348-67-1 Probechem Biochemicals

Chemical Structure : BMS-779788

CAS No.: 918348-67-1

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BMS-779788 (XL-652;BMS-788;EXEL-04286652)

货号: PC-45748Not For Human Use, Lab Use Only.

BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).

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10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).
BMS-779788 only has activity for PXR (ECU0=2 uM) in a panel of 14 NHRs.
BMS-779788 induces LXR target genes in blood in vivo (EC50=610 nM).
BMS-779788 increases in biliary cholesterol and decreases in phospholipid and bile acid in animal models.

物理化学性质&存储条件

分子量	509.0594
分子式	C28H29ClN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	1H-Imidazole-4-methanol, 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-

参考文献

1. Kick E, et al. Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7.

2. Kirchgessner TG, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):305-14.

3. Adams ML, et al. J Pharm Sci. 2016 Apr;105(4):1478-88.

BMS-779788 (XL-652;BMS-788;EXEL-04286652)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-779788 (XL-652;BMS-788;EXEL-04286652)

生物&药学活性

物理化学性质&存储条件

参考文献

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