BMS-754807 | IGF1R/InsR inhibitor | Probechem Biochemicals

Chemical Structure : BMS-754807

CAS No.: 1001350-96-4

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BMS-754807 (BMS 754807;BMS754807)

货号: PC-42444Not For Human Use, Lab Use Only.

BMS-754807 (BMS 754807, BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.

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1 mg (Free Sample)	￥280	In stock
10 mg	￥1480	In stock
25 mg	￥2780	In stock
50 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

BMS-754807 (BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.
BMS-754807 shows additional off-target activities Met, RON, TrkA, TrkB, AurA, and AurB (IC50=5-45 nM) in a panel of 27 kinases.
BMS-754807 inhibits the growth of a broad range of human tumor types in vitro (IC50=5-365 nM), induces PARP and Caspase 3 cleavage, promotes apoptosis.
BMS-754807 exhibits tumor growth inhibition in xenograft tumor models.

物理化学性质&存储条件

分子量	461.4948
分子式	C23H24FN9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-, (2S)-

参考文献

1. Wittman MD, et al. Mol Cancer Ther. 2009 Dec;8(12):3341-9.

2. Carboni JM, et al. Mol Cancer Ther. 2009 Dec;8(12):3341-9.

3. Dinchuk JE, et al. Endocrinology. 2010 Sep;151(9):4123-32.

4. Huang F, et al. Cancer Res. 2010 Sep 15;70(18):7221-31.

BMS-754807 (BMS 754807;BMS754807)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-754807 (BMS 754807;BMS754807)

生物&药学活性

物理化学性质&存储条件

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