BMS-711939 | PPARα agonist | Probechem Biochemicals

Chemical Structure : BMS-711939

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BMS-711939 (BMS 711939;BMS711939)

货号: PC-61068Not For Human Use, Lab Use Only.

BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.

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生物&药学活性

BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.
BMS-711939 shows much lower potency against mouse PPARα than human PPARα.
BMS-711939 robustly increases apolipoprotein (Apo) A1 and high-density lipoprotein cholesterol in human ApoA1 transgenic mice and lower low-density lipoprotein-cholesterol and triglycerides in fat-fed hamsters.
BMS-711939 also prevents the LXR agonist-induced elevation of serum triglycerides.

物理化学性质&存储条件

分子量	462.858
分子式	C22H20ClFN2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[5-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]-2-fluorophenyl]methyl]-N-(methoxycarbonyl)-glycine

参考文献

1. Shi Y, et al. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4.

2. Mukherjee R, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.

BMS-711939 (BMS 711939;BMS711939)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-711939 (BMS 711939;BMS711939)

生物&药学活性

物理化学性质&存储条件

参考文献

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