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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-BMS-707035
BMS-707035

Chemical Structure : BMS-707035

CAS No.: 729607-74-3

BMS-707035 (BMS 707035;BMS707035)

货号: PC-43448Not For Human Use, Lab Use Only.

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM..

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10 mg ¥1008.0 In stock
50 mg ¥3520 In stock
100 mg ¥5760 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM.

HIV Infection

Phase 2 Discontinued

物理化学性质&存储条件

分子量 410.42
分子式 C17H19FN4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-

参考文献

1. Dicker IB, et al. J Biol Chem. 2007 Oct 26;282(43):31186-96.

2. Langley DR, et al. Biochemistry. 2008 Dec 23;47(51):13481-8.

3. Al-Mawsawi LQ, et al. Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25.

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