BMS-687681 | CCR2/5 inhibitor | ProbeChem Biochemicals

Chemical Structure : BMS-687681

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BMS-687681 (BMS687681, BMS-681)

货号: PC-60322Not For Human Use, Lab Use Only.

BMS-687681 (BMS-681) is a potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively.

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生物&药学活性

BMS-687681 (BMS-681) is a potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively.
BMS-681 exhibits high selectivity against other chemokine receptors and GPCRs.
BMS-681 shows CCR2 functional assays of monocyte chemotaxis (IC50=0.24 nM) and CD11b upregulation (whole blood IC50=4.7 nM), CCR5 functional assays of human T-cells (IC50=2.3 nM) and whole blood CCR5-mediated CD11b upregulation (IC50=4.3 nM),
BMS-681 is suitable for use in both murine and monkey models of inflammation.

物理化学性质&存储条件

分子量	491.603
分子式	C26H36F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-propylcyclohexyl)-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-2-one

参考文献

1. Zheng Y, et al. Nature. 2016 Dec 15;540(7633):458-461.

2. Carter PH, et al. ACS Med Chem Lett. 2015 Mar 4;6(4):439-44.

BMS-687681 (BMS687681, BMS-681)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BMS-687681 (BMS687681, BMS-681)

生物&药学活性

物理化学性质&存储条件

参考文献

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