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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-BMS-687453
BMS-687453

Chemical Structure : BMS-687453

CAS No.: 1000998-59-3

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BMS-687453 (BMS687453, BMS 687453)

货号: PC-42693Not For Human Use, Lab Use Only.

BMS-687453 (BMS687453) is a potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-687453 (BMS687453) is a potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays.
BMS-687453 has negligible cross-reactivity against a panel of human nuclear hormone receptors including PPARδ.
BMS-687453 demonstrates an excellent pharmacological and safety profile for the treatment of atherosclerosis and dyslipidemia.

物理化学性质&存储条件

分子量 444.8649
分子式 C22H21ClN2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-

参考文献

1. Li J, et al. J Med Chem. 2010 Apr 8;53(7):2854-64.

2. Mukherjee R, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.

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