BMS-615 | TLR789 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-615

CAS No.: 2180127-82-4

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BMS-615 (BMS615, TLR789 inhibitor 7f)

货号: PC-72051Not For Human Use, Lab Use Only.

TLR789 inhibitor 7f (BMS-615) is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

TLR789 inhibitor 7f (BMS-615) is a potent, orally bioavailable antagonist of Toll-like Receptor 7/8/9 (TLR7/8/9) with IC50 of 10/17/700 nM in NF-kB reporter assays, does not inhibit TLR3/4.
TLR789 inhibitor 7f inhibits IL-6 prodcution via TLR7/8/9 inhibitory response in human whole blood (mWB) assays with IC50 of 5.7/5.1/320 nM, respectively.
TLR789 inhibitor 7f effectively blocks cytokine production elicited by treatment with agonists of TLR7 (gardiquimod) or TLR9 (ODN1585) in mouse pharmacodynamic (PD) models, dose-dependently decreases agonist-induced IL-6 production with plasma EC50 of 2.4 nM (TLR7) or 25 nM (TLR9).

物理化学性质&存储条件

分子量	435.612
分子式	C27H37N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-(3,4-dimethoxyphenyl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine

参考文献

1. Christopher P Mussari, et al. ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.

BMS-615 (BMS615, TLR789 inhibitor 7f)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-615 (BMS615, TLR789 inhibitor 7f)

生物&药学活性

物理化学性质&存储条件

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