BMS-570520 | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : BMS-570520

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BMS-570520 (BMS 570520)

货号: PC-73261Not For Human Use, Lab Use Only.

BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.

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生物&药学活性

BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.
BMS-570520 displays reduced inhibition on CYP2D6 (IC50=1300 nM) compared with DPC168 (IC50=30 nM), also possesses >100-fold selectivity over 5-HT2a, DAT and NET.
BMS-570520 showed good activity in murine models of CCR3 antagonism and greater in vitro potency and in vivo in the mouse intranasal eotaxin challenge mode.

物理化学性质&存储条件

分子量	529.675
分子式	C27H36FN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[(3S,4S)-1-acetyl-4-[[(3S)-3-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-3-piperidinyl]-N'-(5-acetyl-4-methyl-2-thiazolyl)-

参考文献

1. James R Pruitt, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.

BMS-570520 (BMS 570520)

生物&药学活性

物理化学性质&存储条件

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BMS-570520 (BMS 570520)

生物&药学活性

物理化学性质&存储条件

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