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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Insulin Receptor-BMS-536924
BMS-536924

Chemical Structure : BMS-536924

CAS No.: 468740-43-4

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BMS-536924 (BMS536924, BMS 536924)

货号: PC-42501Not For Human Use, Lab Use Only.

BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2280 In stock
50 mg ￥3880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.
BMS-536924 is a weak inhibitor of CYP3A4 (IC50=0.5 uM) and potent transactivator of PXR.
BMS-536924 increases expression and activation of various members of the HER family of receptors in ovarian cancer cell lines.
BMS-536924 causes blockade of proliferation, and results in the formation of hollow polarized lumen in MCF7 cells.

物理化学性质&存储条件

分子量 479.9586
分子式 C25H26ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-

参考文献

1. Wittman M, et al. J Med Chem. 2005 Sep 8;48(18):5639-43.

2. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.

3. Litzenburger BC, et al. Clin Cancer Res. 2009 Jan 1;15(1):226-37.

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