BMS-466442 | Probechem Biochemicals

Chemical Structure : BMS-466442

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BMS-466442 (BMS466442;BMS 466442)

货号: PC-36150Not For Human Use, Lab Use Only.

BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively.

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生物&药学活性

BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively; BMS-466442 inhibited asc-1 but was not a competitive substrate for this transporter, BMS-466442 is the first reported selective inhibitor of the asc-1 transporter.

物理化学性质&存储条件

分子量	524.577
分子式	C30H28N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-2-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)acetate

参考文献

1. Brown JM, et al. J Neurochem. 2014 Apr;129(2):275-83.

2. Torrecillas IR, et al. ACS Chem Neurosci. 2019 Mar 14. doi: 10.1021/acschemneuro.9b00019.

BMS-466442 (BMS466442;BMS 466442)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-466442 (BMS466442;BMS 466442)

生物&药学活性

物理化学性质&存储条件

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