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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-BMS-345541
BMS-345541

Chemical Structure : BMS-345541

CAS No.: 445430-58-0

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BMS-345541 (BMS345541, BMS 345541)

货号: PC-42632Not For Human Use, Lab Use Only.

BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM, less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM, less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.
BMS-345541 inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM.
BMS-345541 has excellent pharmacokinetics in mice.

物理化学性质&存储条件

分子量 255.3183
分子式 C14H17N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-

参考文献

1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6.

2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9.

3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.

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