BMS-22 |CAS: 445479-97-0 Probechem Biochemicals

首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-BMS-22

Chemical Structure : BMS-22

CAS No.: 445479-97-0

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BMS-22 (BMS CCR2 22;CCR2 inhibitor BMS22)

货号: PC-60324Not For Human Use, Lab Use Only.

BMS-22 is a potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-22 is a potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.
BMS-22 displays potent functional antagonism (calcium flux IC50=18 nM and chemotaxis IC 50=1 nM).

物理化学性质&存储条件

分子量	593.66
分子式	C28H34F3N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

参考文献

1. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.

2. Cherney RJ, et al. J Med Chem. 2008 Feb 28;51(4):721-4.

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BMS-22 (BMS CCR2 22;CCR2 inhibitor BMS22)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-22 (BMS CCR2 22;CCR2 inhibitor BMS22)

生物&药学活性

物理化学性质&存储条件

参考文献

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