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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-BMS-195614
BMS-195614

Chemical Structure : BMS-195614

CAS No.: 182135-66-6

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BMS-195614 (BMS 614, BMS195614)

货号: PC-20198Not For Human Use, Lab Use Only.

BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding.

    物理化学性质&存储条件

    分子量 448.52
    分子式 C29H24N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxamido)benzoic acid

    参考文献

    1. M Géhin, et al. Chem Biol. 1999 Aug;6(8):519-29.

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