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首页-小分子抑制剂&激动剂-Others-Regulators of G protein signaling (RGS)-BMS-192364
BMS-192364

Chemical Structure : BMS-192364

CAS No.: 202822-21-7

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BMS-192364 (BMS192364)

货号: PC-23050Not For Human Use, Lab Use Only.

BMS-192364 is a small molecule inhibitor of muscarinic G-protein coupled receptor (GPCR) signaling involving G-αq (G-protein alpha subunit), likely acts at the intersection of RGS and G-αq proteins, resulting in the downregulation of GPCR signaling, reduced calcium fluxes, and reduced muscle contraction.

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5 mg ￥2880 In stock
10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-192364 is a small molecule inhibitor of muscarinic G-protein coupled receptor (GPCR) signaling involving G-αq (G-protein alpha subunit) and an RGS protein agonist, likely acts at the intersection of RGS and G-αq proteins, resulting in the downregulation of GPCR signaling, reduced calcium fluxes, and reduced muscle contraction.

物理化学性质&存储条件

分子量 355.70
分子式 C15H9ClF3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-5-[4-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

参考文献

1. Kevin Fitzgerald, et al. PLoS Genet. 2006 Apr;2(4):e57.

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