BMS-191011 (BMS-A) | KCa1.1/BK opener | Probechem Biochemicals

Chemical Structure : BMS-191011

CAS No.: 202821-81-6

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BMS-191011 (BMS-A, BMS191011)

货号: PC-38451Not For Human Use, Lab Use Only.

BMS-191011 (BMS-A) is a small molecule activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels, increases current to 126% over control at 1 uM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

BMS-191011 (BMS-A) is a small molecule activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels, increases current to 126% over control at 1 uM.
BMS-191011 (10-100 ug/kg, i.v.) increased the diameter of retinal arterioles without altering systemic blood pressure and heart rate significantly.
BMS-191011 could completely abolished iberiotoxin-induced vasodilator effects of acetylcholine on retinal arterioles in non-diabetic rats.

物理化学性质&存储条件

分子量	370.7
分子式	C16H10ClF3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

参考文献

1. Mori A, et al. Biol Pharm Bull. 2011;34(1):150-2.

2. Romine JL, et al. J Med Chem. 2007 Feb 8;50(3):528-42.

3. Hewawasam P, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1695-8.

4. Mori A, et al. Eur J Pharmacol. 2011 Nov 1;669(1-3):94-9.

BMS-191011 (BMS-A, BMS191011)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BMS-191011 (BMS-A, BMS191011)

生物&药学活性

物理化学性质&存储条件

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