BMS-189453 |CAS:166977-43-1 Probechem Biochemicals

Chemical Structure : BMS-189453

CAS No.: 166977-43-1

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BMS-189453 (BMS189453;BMS453)

货号: PC-70294Not For Human Use, Lab Use Only.

BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.
BMS-189453 binds to RAR receptors and transrepresses AP-1, inhibits the growth of normal breast cells (HMEC and 184) and T47D breast cancer cells.
BMS-189453 increases p21, decrease CDK2 kinase activity, which in turn leads to hypophosphorylation of Rb and G1 arrest.

物理化学性质&存储条件

分子量	380.5
分子式	C27H24O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]- (9CI)

参考文献

1. Chen JY, et al. EMBO J. 1995 Mar 15;14(6):1187-97.

2. Yang L, et al. Oncogene. 2001 Nov 29;20(55):8025-35.

3. Yang L, et al. Breast Cancer Res Treat. 1999 Aug;56(3):277-91.

BMS-189453 (BMS189453;BMS453)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BMS-189453 (BMS189453;BMS453)

生物&药学活性

物理化学性质&存储条件

参考文献

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