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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Autotaxin-BMP22
BMP22

Chemical Structure : BMP22

CAS No.: 1306684-90-1

BMP22

货号: PC-23708Not For Human Use, Lab Use Only.

BMP22 is a potent inhibitor of autotaxin (ATX, NPP2) with Ki/IC50 of 0.17/0.27 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMP22 is a potent inhibitor of autotaxin (ATX, NPP2) with Ki/IC50 of 0.17/0.27 uM.
BMP22 inhibited ATX-dependent invasion of rat MM1 hepatoma cells of mesothelial cell and human umbilical cord vascular endothelial cell (HUVEC) monolayers in vitro.
BMP22 showed a profound reduction in lung foci in vivo using the B16-F10 syngeneic melanoma metastasis model in C57BL/6 mice.

物理化学性质&存储条件

分子量 426.49
分子式 C22H37Na2O3P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

sodium (4-pentadecylbenzyl)phosphonate

参考文献

1. Sue-Chin Lee, et al. Mol Cancer Res. 2015 Jan;13(1):174-85.

2. Renuka Gupte, et al. ChemMedChem. 2011 May 2;6(5):922-35.

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