BML-281 (CAY10603) | HDAC6 inhibitor| Probechem Biochemicals

Chemical Structure : BML-281

CAS No.: 1045792-66-2

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BML-281 (CAY10603, BML281)

货号: PC-60692Not For Human Use, Lab Use Only.

BML-281 (CAY10603) is a potent, selective HDAC6 inhibitor with IC50 of 0.002 nM, weakly inhibits HDAC3 (IC50=0.42 nM) and >50,000-fold selectivity over HDAC1/2/8/10.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

BML-281 (CAY10603) is a potent, selective HDAC6 inhibitor with IC50 of 0.002 nM, weakly inhibits HDAC3 (IC50=0.42 nM) and >50,000-fold selectivity over HDAC1/2/8/10.
BML-281 (CAY10603) blocks pancreatic cancer cell growth with IC50 of <1 uM.
BML-281 (CAY10603) selectively reduces lamina propria B-cell infiltrate and suppresses CD19+ B lymphocyte influx into DSS-inflamed lamina propria, elicits broad-spectrum anti-inflammatory effects in DSS-induced colitis in mice.

物理化学性质&存储条件

分子量	446.5
分子式	C22H30N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide

参考文献

1. Lohman RJ, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):387-96.

2. Do A, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):140-151.

3. Kozikowski AP, et al. J Med Chem. 2008 Aug 14;51(15):4370-3.

BML-281 (CAY10603, BML281)

生物&药学活性

物理化学性质&存储条件

参考文献

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BML-281 (CAY10603, BML281)

生物&药学活性

物理化学性质&存储条件

参考文献

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