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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-BML-277
BML-277

Chemical Structure : BML-277

CAS No.: 516480-79-8

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BML-277 (BML277)

货号: PC-49284Not For Human Use, Lab Use Only.

BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1180 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.
BML-277 dose dependently protects human CD4+ and CD8+ T-cells from apoptosis due to ionizing radiation.
BML-277 specifically inhibit CHK2 phosphorylation at Thr68 at different time course, but not CHK1 phosphorylation.
BML-277 significantly promoted pneumonia symptoms, including mortality, lung infiltration of immune cells, and the abundance of lung pro-inflammatory cytokines in vivo.
BML-277 reduced protein poly(ADP-ribosyl)ation (PARylation), FANCD2 monoubiquitination, homologous recombination and OR CRC cell growth in vitro and in vivo.

物理化学性质&存储条件

分子量 363.80
分子式 C20H14ClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide

参考文献

1. Kristen L Arienti, et al. J Med Chem. 2005 Mar 24;48(6):1873-85.

2. Xie F, et al. Exp Lung Res. 2022 Jan 25:1-8.

3. Hsieh CC, et al. Br J Cancer. 2022 Aug 23. doi: 10.1038/s41416-022-01946-9.

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