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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-BML-260
BML-260

Chemical Structure : BML-260

CAS No.: 862827-45-0

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BML-260 (BML260)

货号: PC-49744Not For Human Use, Lab Use Only.

BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes.
    BML-260 activates UCP1 expression (both the mRNA level and the protein level) and increases mitochondrial activity in brown adipocytes.
    BML-260 stimulates the expression of UCP1 in adipocytes in a JSP-1 independent manner.
    BML-260 upregulates thermogenic and muscle program genes.
    BML-260 induces UCP1 expression in white adipocytes and enhances thermogenesis, activates UCP1 and increases thermogenesis in vivo.
    JSP-1 is a dual-specific phosphatase encoded by DUSP22 (dual specificity phosphatase 22), which is also known as JKAP (JNK pathway-associated phosphatase), JSP-1 is a JNK activator, and a proposed target for the treatment of inflammatory and proliferative disorders associated with dysfunctional JNK signaling.

    物理化学性质&存储条件

    分子量 341.40
    分子式 C17H11NO3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-4-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid

    参考文献

    1. Feng Z, et al. Theranostics. 2019 May 26;9(12):3501-3514.

    2. Albayrak E, et al. J Cell Biochem. 2022 Dec;123(12):2009-2029.

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