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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-BMF-219
BMF-219

Chemical Structure : BMF-219

CAS No.: 2448172-22-1

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BMF-219 (Icovamenib, BMF219)

货号: PC-25566Not For Human Use, Lab Use Only.

BMF-219 (Icovamenib) is a potent, selective and covalent irreversible menin inhibitor, inhibits the growth of KRAS-mutated solid tumors with G12C, G12D, and G12V KRAS mutations.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMF-219 (Icovamenib) is a potent, selective and covalent irreversible menin inhibitor, inhibits the growth of KRAS-mutated solid tumors with G12C, G12D, and G12V KRAS mutations.

物理化学性质&存储条件

分子量 566.67
分子式 C31H34N8O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-((3-Acrylamidopiperidin-1-yl)methyl)-N-(4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)picolinamide

参考文献

1. Brian Law, et al. Cancer Res (2022) 82 (12_Supplement): 2665.

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