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首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Fms (CSF1R)-BLZ945
BLZ945

Chemical Structure : BLZ945

CAS No.: 953769-46-5

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BLZ945 (Sotuletinib, BLZ-945)

货号: PC-43194Not For Human Use, Lab Use Only.

Sotuletinib (BLZ945) is a potent, selective, brain-penetrant CSF-1R inhibitor with biochemical IC50 of 1 nM, displays >3,200-fold selectivity over other kinases (c-Kit, PDGFR-β, Flt3, Abl, etc.).

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sotuletinib (BLZ945) is a potent, selective, brain-penetrant CSF-1R inhibitor with biochemical IC50 of 1 nM, displays >3,200-fold selectivity over other kinases (c-Kit, PDGFR-β, Flt3, Abl, etc.).
Sotuletinib (BLZ945) inhibits CSF-1-dependent proliferation in bone marrow-derived macrophages (BMDMs) with EC50 of 67 nM, and decreases CSF-1R phosphorylation.
Sotuletinib (BLZ945) blocks glioma progression and significantly improves survival, efficiently limits tumor progression combining with PD-1/PD-L1 blocking antibodies in neuroblastoma.

物理化学性质&存储条件

分子量 398.4787
分子式 C20H22N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

2-Pyridinecarboxamide, 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-

参考文献

1. Pyonteck SM, et al. Nat Med. 2013 Oct;19(10):1264-72.

2. Pass HI, et al. Oncotarget. 2016 Aug 30;7(35):56408-56421.

3. Mao Y, et al. Clin Cancer Res. 2016 Aug 1;22(15):3849-59.

4. Quail DF, et al. Science. 2016 May 20;352(6288):aad3018.

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