BLU-782 | ALK2 inhibitor | Probechem Biochemicals

Chemical Structure : BLU-782

CAS No.: 2141955-96-4

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货号: PC-35519Not For Human Use, Lab Use Only.

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.

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生物&药学活性

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.

BLU-782 is selective for ALK2R206H over other BMP Type I ALK family receptors.

BLU-782 prevents injury-induced heterotopic ossification (HO) in an ALK2 R206H transgenic mouse model of FOP.

BLU-782 is an investigational ALK2 inhibitor in development for fibrodysplasia ossificans progressiva (FOP).

分子量	562.715
分子式	C31H42N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester

1. PCT Int. Appl. (2017), WO 2017181117 A1 20171019.