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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-BLU-554
BLU-554

Chemical Structure : BLU-554

CAS No.: 1707289-21-1

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BLU-554 (Fisogatinib;BLU554)

货号: PC-42173Not For Human Use, Lab Use Only.

BLU-554 (Fisogatinib, BLU554) is a novel potent, highly selective and orally bioavailable inhibitor of FGFR4 with IC50 of 5 nM.

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10 mg ￥980 In stock
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50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BLU-554 (Fisogatinib, BLU554) is a novel potent, highly selective and orally bioavailable inhibitor of FGFR4 with IC50 of 5 nM.
BLU-554 inhibits hepatocellular carcinoma (HCC) with FGFR4 pathway activation.
BLU-554 targets FGFR4 while sparing other members of the FGFR family and showing little to no inhibition of all other kinases.

物理化学性质&存储条件

分子量 503.3777
分子式 C24H24Cl2N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 25 mg/mL
Chemical Name/SMILES

2-Propenamide, N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-

参考文献

1. Richard Kim, et al. EJC. December 2016, Volume 69, Supplement 1, Page S41.

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