BL001

Chemical Structure : BL001

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货号: PC-23783Not For Human Use, Lab Use Only.

BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1.

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生物&药学活性

BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1.
BL001 improves islet survival and blunts development of diabetes diabetes in mice.
BL001 decreases insulitis and modulates the blood cytokine profile.
BL001 promotes a pancreatic anti-inflammatory/tolerogenic environment.
BL001 promotes beta and alpha cell mass expansion in immunized RIP-B7.1 mice.
BL001 protects human islets against apoptosis and rescues insulin secretion in islets of type 2 diabetic donors.

物理化学性质&存储条件

分子量	415.62
分子式	C29H37NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3a(1H)-Pentalenamine, 2,3,6,6a-tetrahydro-4-(3-methoxyphenyl)-N-phenyl-5-[(1E)-1-propyl-1-penten-1-yl]-, (3aR,6aS)-rel-

参考文献

1. Cobo-Vuilleumier N, et al. Nat Commun. 2018 Apr 16;9(1):1488.

2. Martin Vázquez E, et al. iScience. 2022 May 2;25(5):104345.

3. Whitby RJ, et al. J Med Chem. 2006 Nov 16;49(23):6652-5.

BL001

生物&药学活性

物理化学性质&存储条件

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BL001

生物&药学活性

物理化学性质&存储条件

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