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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-BL-140
BL-140

Chemical Structure : BL-140

CAS No.: 663620-66-4

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BL-140 (BL 140, BL140)

货号: PC-60391Not For Human Use, Lab Use Only.

BL-140 is a potent, specific p110β inhibitor with IC50 of 5.74 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BL-140 is a potent, specific p110β inhibitor with IC50 of 5.74 nM.
    BL-140 dispalys 150-fold and 745-fold selectivity over p110α or p110δ.
    BL-140 blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.

    物理化学性质&存储条件

    分子量 371.459
    分子式 C18H21N5O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-methyl-2-morpholino-9-(1-(thiazol-2-ylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

    参考文献

    1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198.

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