BL-1249 |CAS:18200-13-0 Probechem Biochemicals

Chemical Structure : BL-1249

CAS No.: 18200-13-0

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BL-1249 (BL 1249;BL1249)

货号: PC-60338Not For Human Use, Lab Use Only.

BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.

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10 mg	￥2380	In stock
25 mg	￥3980	In stock
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生物&药学活性

BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.
BL-1249 decreases the number of isovolumic contractions, without significantly affecting blood pressure, in anesthetized rat models.
BL-1249 exhibits bladder versus vascular selectivity both in vitro and in vivo.

物理化学性质&存储条件

分子量	291.35
分子式	C17H17N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

参考文献

1. Tertyshnikova S, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):250-9.

2. Veale EL, et al. Mol Pharmacol. 2014 May;85(5):671-81.

BL-1249 (BL 1249;BL1249)

生物&药学活性

物理化学性质&存储条件

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BL-1249 (BL 1249;BL1249)

生物&药学活性

物理化学性质&存储条件

参考文献

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