BK channel modulator BC5 | BK channel modulator | Probechem Biochemicals

Chemical Structure : BK channel modulator BC5

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BK channel modulator BC5 (BC5)

货号: PC-20753Not For Human Use, Lab Use Only.

BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.

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生物&药学活性

BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.
BC5 shifted the voltage-dependent activation (GV relation) of BK channels to more negative voltages (EC50=2.5 uM).
BC5 also inhibited the outward BK currents at positive voltages in the cytosolic side of the membrane patch.
BC5 perturbs Ca2+-dependent activation, interactions with the allosteric pathway for coupling Ca2+ binding to pore opening.

物理化学性质&存储条件

分子量	328.42
分子式	C18H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	NC(NCCCC(N)C(CC1=CC(OC)=C2C=CC=CC2=C1)=O)=N

参考文献

1. Guohui Zhang, et al. Nat Commun. 2022 Nov 9;13(1):6784.

BK channel modulator BC5 (BC5)

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物理化学性质&存储条件

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BK channel modulator BC5 (BC5)

生物&药学活性

物理化学性质&存储条件

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