BKT300 | PRC1 inhibitor | Probechem Biochemicals

Chemical Structure : BKT300

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BKT300 (BKT-300)

货号: PC-24282Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

BKT300 is a small molecule inhibitor of leukemic cell migration and survival by targeting the PRC1 pathways, efficiently and specifically binds protein regulator of cytokinesis 1 (PRC1) with SPR Kd of 28.3 nM.
BKT300 does not bind to CDC25C or DCAF11.
BKT300 inhibits the migration of AML THP-1 cells toward monocyte chemotactic protein-1 (MCP-1).
BKT300 inhibits the formation and organization of actin filaments and microtubules.
BKT300 arrests cancer cells at G2/M and induces apoptotic cell death through the caspase 3 pathway, downregulates the expression of CDC25C but not CDC2 and upregulates p21.
BKT300 arrests PRC1 in a phosphorylated state at position T481.
BKT300 inhibits tumor growth and induces tumor regression in xenograft mouse models of AML.

物理化学性质&存储条件

分子量	399.44
分子式	C22H25NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-hydroxy-2-methoxyphenoxy)-6-methoxy-3-pentylquinoline-2,4-diol

参考文献

1. Amnon Peled, et al. Res Sq [Preprint]. 2025 Feb 19:rs.3.rs-6017610.

BKT300 (BKT-300)

生物&药学活性

物理化学性质&存储条件

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BKT300 (BKT-300)

生物&药学活性

物理化学性质&存储条件

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