BKS-112 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : BKS-112

加入收藏

BKS-112 (BKS112)

货号: PC-25804Not For Human Use, Lab Use Only.

BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1.
BKS-112 exhibits selective cytotoxicity toward cancer cells while showing significantly reduced toxicity in MCF-10A normal cells.
BKS-112 exhibits selective cytotoxicity toward cancer cells while showing significantly reduced toxicity in MCF-10A normal cells.
BKS-112 (50 uM) significant increases the expression of acetylated histones in MDA-MB-231 cells.
BKS-112 reduces cell migration, demonstrating anti-metastatic potential, induces G1 phase cell cycle arrest and modulates key regulators, including cyclins and cyclin-dependent kinases (CDKs).
BKS-112 also elevatesreactive oxygen species (ROS) levels, affecting apoptosis-related PI3K/AKT signaling, triggers autophagy by upregulating LC3 and Atg-7 expression.

物理化学性质&存储条件

分子量	292.33
分子式	C14H13FN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-hydroxy-3-(2-(4-fluorostyryl) thiazol-4-yl) propanamide

参考文献

1. Nam G, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3408-3420.

2. Gali S, et al. Antioxidants (Basel). 2025 Oct 28;14(11):1291.

BKS-112 (BKS112)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BKS-112 (BKS112)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.