BKIDC-1553 | Hexokinase 2 inhibitor | Probechem Biochemicals

Chemical Structure : BKIDC-1553

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BKIDC-1553 (BKIDC1553)

货号: PC-22035Not For Human Use, Lab Use Only.

BKIDC-1553 is a specific small molecule inhibitor with antiglycolytic activity in prostate cancer cell lines, inhibits hexokinase 2 (HK2).

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50 mg		Get quote
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200 mg		Get quote
1 g		Get quote

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生物&药学活性

BKIDC-1553 is a specific small molecule inhibitor with antiglycolytic activity in prostate cancer cell lines, inhibits hexokinase 2 (HK2).
BKIDC-1553 display selective growth inhibition across multiple prostate cancer models.
BKIDC-1553 is active in suppressing the growth of most AR positive and AR negative metastatic PCa cell lines but was not effective in suppressing the growth of normal fibroblast cells or bone, lymphocyte, or hepatocyte derived cancer cell lines.
BKIDC-1553 demonstrates promising activity in a preclinical xenograft model of advanced prostate cancer, equivalent to that of enzalutamide.
BKIDC-1553 demonstrates safety and pharmacologic properties consistent with a compound that can be taken into human studies.

物理化学性质&存储条件

分子量	389.46
分子式	C22H23N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-amino-3-(6-cyclopropoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropan-2-ol

参考文献

1. Takuma Uo, et al. Mol Cancer Ther. 2024 Mar 20. doi: 10.1158/1535-7163.MCT-23-0540.

BKIDC-1553 (BKIDC1553)

生物&药学活性

物理化学性质&存储条件

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BKIDC-1553 (BKIDC1553)

生物&药学活性

物理化学性质&存储条件

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