BK697 | FIRΔexon2 inhibitor | Probechem Biochemicals

Chemical Structure : BK697

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BK697 (BK 697)

货号: PC-21625Not For Human Use, Lab Use Only.

BK697 is a small molecule targeting FIRΔexon2, potentially interacts with FIRΔexon2, significantly suppresses the FIRΔexon2 expression and inhibits tumor cell growth and several rRNA expressions.

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1 g		Get quote

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生物&药学活性

BK697 is a small molecule targeting FIRΔexon2, potentially interacts with FIRΔexon2, significantly suppresses the FIRΔexon2 expression and inhibits tumor cell growth and several rRNA expressions.
BK697 effectively suppressed HepG2 cell growth with an IC50 of 17.8 µM.
BK697 suppresses the expressions of FIR and FIRΔexon2 mRNA levels in HepG2 cells, reduces the expressions of RPS6, RPS10, RPS15A, RPL30, and RPL23A.
BK697 could salvage FIR homodimerization and was used as a potential therapeutic agent.
BK697 affected FIR family, E-cadherin, Snai1, and BRG1 expression.
FIRΔexon2, a dominant negative splicing form of FIR, is scarcely expressed in normal cells but expressed in cancer with c-myc activation.

物理化学性质&存储条件

分子量	440.57
分子式	C24H24O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3,3'-(5-(4-(tert-butyl)styryl)-1,3-phenylene)bis(2-thioxopropanoic acid)

参考文献

1. Kouichi Kitamura, et al. Int J Mol Sci. 2023 Dec 11;24(24):17341.

2. Guzhanuer Ailiken, et al. Oncogenesis. 2020 Feb 18;9(2):26.

BK697 (BK 697)

生物&药学活性

物理化学性质&存储条件

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BK697 (BK 697)

生物&药学活性

物理化学性质&存储条件

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