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首页-小分子抑制剂&激动剂-Others-Other Targets-BJP-07-017-3
BJP-07-017-3

Chemical Structure : BJP-07-017-3

CAS No.: 2468783-22-2

BJP-07-017-3

货号: PC-23441Not For Human Use, Lab Use Only.

BJP-07-017-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=15 nM), IC50 of 9 nM in DELFIA assays, covalently targets Cys113, a highly conserved cysteine located in the Pin1 active site.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BJP-07-017-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=15 nM), IC50 of 9 nM in DELFIA assays, covalently targets Cys113, a highly conserved cysteine located in the Pin1 active site.

物理化学性质&存储条件

分子量 709.25
分子式 C35H45ClN8O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-((S)-1-(((S)-1-amino-1-oxo-5-ureidopentan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-1-(N-(2-chloroacetyl)-N-methyl-L-phenylalanyl)piperidine-2-carboxamide

参考文献

1. B. J. Pinch et al., Identification of a potent and selective covalent Pin1 inhibitor. Nat. Chem. Biol. 16, 979–987 (2020).

2. Alboreggia G, et al. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2403330121.

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