BJP-06-005-3

Chemical Structure : BJP-06-005-3

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货号: PC-72215Not For Human Use, Lab Use Only.

BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=48 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.

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生物&药学活性

BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=48 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.
BJP-06–005-3 potently inhibited Pin1 catalytic activity with an apparent Ki of 48 nM in PPIase assays.
BJP-06-005-3 reduced cell viability cross a panel of cancer cell lines in a dose- and time-dependent manner.
BJP-06-005-3 increased phospho-CDK1 Tyr15 in Pin1-WT PDAC cell, but not in Pin1 KO cells, affected expression of downstream Pin1 substrates, increased c-Myc protein levels, cooperated with KRASG12V degradation.

物理化学性质&存储条件

分子量	738.283
分子式	C37H48ClN7O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (S)-2-((S)-2-((S)-1-(N-(2-chloroacetyl)-N-methyl-L-phenylalanyl)piperidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-5-ureidopentanoate

参考文献

1. Benika J Pinch, et al. Nat Chem Biol. 2020 Sep;16(9):979-987.

BJP-06-005-3

生物&药学活性

物理化学性质&存储条件

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BJP-06-005-3

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物理化学性质&存储条件

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